Hello! I'm Matt.
I'm a bioinformatician at UNC Chapel Hill.
I did my PhD here at UNC in Genetics and Molecular Biology, where I studied how chromatin accessibility controls developmental enhancers.
These days I help researchers plan and analyze their genomics experiments, which involves a lot less pipetting.
I'm always up for a chat about science and bioinformatics, so feel free to reach out!
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Niederhuber MJ, Leatham-Jensen M, McKay DJ. (2023)
The SWI/SNF nucleosome remodeler constrains enhancer activity during Drosophila wing development. BioRxiv
Niederhuber MJ, McKay DJ. (2021)
Mechanisms underlying the control of dynamic
regulatory element activity and chromatin accessibility
during metamorphosis. COIS
Nystrom NL*,
Niederhuber MJ*, McKay DJ. (2020)
Expression of E93 provides an instructive
cue to control dynamic enhancer activity and chromatin
accessibility during development.
Development
*equal contributors
Naydich AD, Nangle SN, Bues JJ, Trivedi D, Nissar N,
Inniss MC,
Niederhuber MJ, Way JC, Silver PA,
Riglar DT. (2019)
Synthetic gene circuits enable systems-level
biosensor discovery at the host-microbe interface.
mSystems.
Niederhuber MJ, Lambert TJ, Yapp C, Silver PA,
Polka JK. (2017).
Superresolution microscopy of the
beta-carboxysome reveals a homogenous matrix.
MBoC.
Uyehara CM, Nystrom SL,
Niederhuber MJ,
Leatham-Jensen M, Ma Y, Buttitta LA, McKay DJ.
(2017).
Hormone-dependent control of
developmental timing through regulation of chromatin
accessibility.Genes and Development.
Riglar DT, Giessen TW, Baym M, Kerns JS,
Niederhuber
MJ, Bronson RT, Kotula JW, Gerber GK, Way JC, Silver
PA. (2017).
Engineered bacteria can function in the
mammalian gut long-term as live diagnostics of
inflammation. Nature Biotechnology.
AlphaFold Unlocks Protein Structure
Prediction with Artificial Intelligence
The Pipettepen, 2021.
Trimming the Fat: How Cultured Meat
Could Take on the Meat Industry and Tackle Global
Warming
The Pipettepen, 2021.
UNC Scientists Partner with Citizen
Scientists to Map Earth's River Obstructions
UNC Institute for the Environment, 2019.
no longer available online
How Your Gut Bacteria May Be Talking
To Your Brain
The Pipettepen, 2019.
Why Can't Humans
Hibernate?
North Carolina DNA Day Blog, 2018.
CUT&RUN: A Improved Method for
Studying Protein-DNA Interactions.
Addgene Blog, 2018.
How to Copy DNA: The Invention of the
Polymerase Chain Reaction.
North Carolina DNA Day Blog, 2018.
House Tax Bill Could Lead to
Significant Tax Increase for UNC Grad
Students.
The Pipettepen, 2017.
Making Time Matter: How Hormone Pulses
Direct Chromatin Accessibility During
Development.
The Node, 2017.
The March for Science Raises Concerns
Over Politicization.
The Pipettepen, 2017.
Bionic Plants Detect Explosive
Chemicals.
The Pipettepen, 2016.
Insecticidal Plants: The Tech and
Safety of GM Bt Crops.
Harvard University: Science in the News, 2015.
The Human Microbiome and Media
Confusion.
Harvard University: Science in the News, 2014.
The Fight Over Inoculation During the
1721 Boston Smallpox Epidemic.
Harvard University: Science in the News, 2014.
Yes, This Exists: A Biohacker
Hotline
Popular Science, 2013.
A LLM agent for annotating SRA metadata:
Template for running RStudio Server with a Singularity container:
